CD33 anticorps (AA 15-237)
Aperçu rapide pour CD33 anticorps (AA 15-237) (ABIN1845398)
Antigène
Voir toutes CD33 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 15-237
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Purification
- Purified antibody
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Immunogène
- Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.
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Isotype
- IgG1
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1.0 mg/mL
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Buffer
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- CD33
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Autre désignation
- CD33
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Sujet
- The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.Preferentially binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD).
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Poids moléculaire
- 39.8 kDa
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ID gène
- 945
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UniProt
- P20138
Antigène
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